Assay Detail
Binding
CHEMBL744382
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Displacement of [3H]N-methylscopolamine from rat brain homogenate
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.27 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10272 | BENZETIMIDE | 2.0 | 1 | 7.82 |
| CHEMBL274789 | — | — | 1 | 7.77 |
| CHEMBL10086 | — | — | 1 | 7.68 |
| CHEMBL10278 | — | — | 1 | 7.66 |
| CHEMBL10399 | — | — | 1 | 7.62 |
| CHEMBL273262 | — | — | 1 | 7.58 |
| CHEMBL10097 | — | — | 1 | 7.57 |
| CHEMBL10331 | — | — | 1 | 7.50 |
| CHEMBL10309 | — | — | 1 | 7.42 |
| CHEMBL274817 | — | — | 1 | 7.01 |
| CHEMBL9966 | — | — | 1 | 6.34 |
| CHEMBL274552 | — | — | 1 | 6.30 |
| CHEMBL276237 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10272 | BENZETIMIDE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL274789 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL10086 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL10278 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL10399 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL273262 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL10097 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL10331 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL10309 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL274817 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL9966 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL274552 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL276237 | — | IC50 | = | 500.0 | nM | 6.30 |