Assay Detail
Binding
CHEMBL744478
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Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 5.89 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107679 | — | — | 1 | 6.66 |
| CHEMBL104332 | — | — | 1 | 6.62 |
| CHEMBL326450 | — | — | 1 | 6.47 |
| CHEMBL106219 | — | — | 1 | 6.43 |
| CHEMBL105945 | — | — | 1 | 6.38 |
| CHEMBL107444 | — | — | 1 | 6.29 |
| CHEMBL106224 | — | — | 1 | 6.29 |
| CHEMBL59898 | — | — | 1 | 6.27 |
| CHEMBL106218 | — | — | 1 | 6.15 |
| CHEMBL420662 | — | — | 1 | 5.97 |
| CHEMBL320465 | — | — | 1 | 5.97 |
| CHEMBL104574 | — | — | 1 | 5.87 |
| CHEMBL105148 | — | — | 1 | 5.87 |
| CHEMBL104693 | — | — | 1 | 5.84 |
| CHEMBL104803 | — | — | 1 | 5.66 |
| CHEMBL105122 | — | — | 1 | 5.66 |
| CHEMBL318995 | — | — | 1 | 5.66 |
| CHEMBL106505 | — | — | 1 | 5.63 |
| CHEMBL105593 | — | — | 1 | 5.61 |
| CHEMBL105674 | — | — | 1 | 5.49 |
| CHEMBL280220 | — | — | 1 | 5.42 |
| CHEMBL106259 | — | — | 1 | 5.39 |
| CHEMBL105160 | — | — | 1 | 5.34 |
| CHEMBL104804 | — | — | 1 | 5.27 |
| CHEMBL104210 | — | — | 1 | 5.14 |
| CHEMBL107680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107679 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL104332 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL326450 | — | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL106219 | — | Ki | = | 371.54 | nM | 6.43 |
| CHEMBL105945 | — | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL107444 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL106224 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL59898 | — | Ki | = | 537.03 | nM | 6.27 |
| CHEMBL106218 | — | Ki | = | 707.95 | nM | 6.15 |
| CHEMBL420662 | — | Ki | = | 1071.52 | nM | 5.97 |
| CHEMBL320465 | — | Ki | = | 1071.52 | nM | 5.97 |
| CHEMBL104574 | — | Ki | = | 1348.96 | nM | 5.87 |
| CHEMBL105148 | — | Ki | = | 1348.96 | nM | 5.87 |
| CHEMBL104693 | — | Ki | = | 1445.44 | nM | 5.84 |
| CHEMBL104803 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL105122 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL318995 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL106505 | — | Ki | = | 2344.23 | nM | 5.63 |
| CHEMBL105593 | — | Ki | = | 2454.71 | nM | 5.61 |
| CHEMBL105674 | — | Ki | = | 3235.94 | nM | 5.49 |
| CHEMBL280220 | — | Ki | = | 3801.89 | nM | 5.42 |
| CHEMBL106259 | — | Ki | = | 4073.8 | nM | 5.39 |
| CHEMBL105160 | — | Ki | = | 4570.88 | nM | 5.34 |
| CHEMBL104804 | — | Ki | = | 5370.32 | nM | 5.27 |
| CHEMBL104210 | — | Ki | = | 7244.36 | nM | 5.14 |
| CHEMBL107680 | — | Ki | > | 26915.35 | nM | - |