Compound Detail
CHEMBL107679
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Basic Information
| ChEMBL ID | CHEMBL107679 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QTRFYRFDHGEFHT-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
420.5
MW (Da)
4.60
ALogP
6
HBA
0
HBD
52.9
PSA (Ų)
0.58
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | Ki | 6.96 | 6.96 | 109.7 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | Ki | 6.66 | 6.66 | 218.8 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | Ki | 6.58 | 6.58 | 263.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | Ki | 5.88 | 5.88 | 1318.3 | 1 |
| Muscarinic acetylcholine receptor M5 CHEMBL2035 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M4 | Ki | = | 109.65 | nM | 6.96 | Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M4 in t... | 12086495 |
| Muscarinic acetylcholine receptor M2 | Ki | = | 218.78 | nM | 6.66 | Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in ... | 12086495 |
| Muscarinic acetylcholine receptor M3 | Ki | = | 263.03 | nM | 6.58 | Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M3 in t... | 12086495 |
| Muscarinic acetylcholine receptor M1 | Ki | = | 1318.26 | nM | 5.88 | Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M1 in t... | 12086495 |
| Muscarinic acetylcholine receptor M5 | Ki | = | 2511.89 | nM | 5.6 | Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in t... | 12086495 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12086495 | 10.1021/jm011116o | Muscarinic acetylcholine receptor M1 | 1 |
| 12086495 | 10.1021/jm011116o | Muscarinic acetylcholine receptor M2 | 1 |
| 12086495 | 10.1021/jm011116o | Muscarinic acetylcholine receptor M3 | 1 |
| 12086495 | 10.1021/jm011116o | Muscarinic acetylcholine receptor M4 | 1 |
| 12086495 | 10.1021/jm011116o | Muscarinic acetylcholine receptor M5 | 1 |
Data from ChEMBL 36 via Core Engine