Assay Detail
Binding
CHEMBL746412
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Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M1 in transfected CHO cells.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 5.68 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104332 | — | — | 1 | 6.70 |
| CHEMBL106219 | — | — | 1 | 6.44 |
| CHEMBL104693 | — | — | 1 | 6.06 |
| CHEMBL318995 | — | — | 1 | 6.06 |
| CHEMBL104574 | — | — | 1 | 5.93 |
| CHEMBL105945 | — | — | 1 | 5.93 |
| CHEMBL420662 | — | — | 1 | 5.88 |
| CHEMBL106505 | — | — | 1 | 5.88 |
| CHEMBL107679 | — | — | 1 | 5.88 |
| CHEMBL59898 | — | — | 1 | 5.88 |
| CHEMBL106224 | — | — | 1 | 5.88 |
| CHEMBL106218 | — | — | 1 | 5.82 |
| CHEMBL105122 | — | — | 1 | 5.75 |
| CHEMBL107444 | — | — | 1 | 5.70 |
| CHEMBL320465 | — | — | 1 | 5.69 |
| CHEMBL105148 | — | — | 1 | 5.66 |
| CHEMBL104804 | — | — | 1 | 5.60 |
| CHEMBL105160 | — | — | 1 | 5.51 |
| CHEMBL280220 | — | — | 1 | 5.48 |
| CHEMBL105674 | — | — | 1 | 5.29 |
| CHEMBL104803 | — | — | 1 | 5.12 |
| CHEMBL326450 | — | — | 1 | 4.88 |
| CHEMBL104210 | — | — | 1 | 4.69 |
| CHEMBL106259 | — | — | 1 | 4.66 |
| CHEMBL105593 | — | — | 1 | - |
| CHEMBL107680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104332 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL106219 | — | Ki | = | 363.08 | nM | 6.44 |
| CHEMBL104693 | — | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL318995 | — | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL104574 | — | Ki | = | 1174.9 | nM | 5.93 |
| CHEMBL105945 | — | Ki | = | 1174.9 | nM | 5.93 |
| CHEMBL420662 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL106505 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL107679 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL59898 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL106224 | — | Ki | = | 1318.26 | nM | 5.88 |
| CHEMBL106218 | — | Ki | = | 1513.56 | nM | 5.82 |
| CHEMBL105122 | — | Ki | = | 1778.28 | nM | 5.75 |
| CHEMBL107444 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL320465 | — | Ki | = | 2041.74 | nM | 5.69 |
| CHEMBL105148 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL104804 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL105160 | — | Ki | = | 3090.3 | nM | 5.51 |
| CHEMBL280220 | — | Ki | = | 3311.31 | nM | 5.48 |
| CHEMBL105674 | — | Ki | = | 5128.61 | nM | 5.29 |
| CHEMBL104803 | — | Ki | = | 7585.78 | nM | 5.12 |
| CHEMBL326450 | — | Ki | = | 13182.57 | nM | 4.88 |
| CHEMBL104210 | — | Ki | = | 20417.38 | nM | 4.69 |
| CHEMBL106259 | — | Ki | = | 21877.62 | nM | 4.66 |
| CHEMBL105593 | — | Ki | > | 4365.16 | nM | - |
| CHEMBL107680 | — | Ki | > | 21877.62 | nM | - |