Assay Detail
Binding
CHEMBL752414
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Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M3 in transfected CHO cells.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.28 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106219 | — | — | 1 | 7.30 |
| CHEMBL320465 | — | — | 1 | 7.15 |
| CHEMBL106224 | — | — | 1 | 7.15 |
| CHEMBL105148 | — | — | 1 | 7.04 |
| CHEMBL104693 | — | — | 1 | 7.00 |
| CHEMBL326450 | — | — | 1 | 6.82 |
| CHEMBL106218 | — | — | 1 | 6.66 |
| CHEMBL105122 | — | — | 1 | 6.64 |
| CHEMBL280220 | — | — | 1 | 6.64 |
| CHEMBL59898 | — | — | 1 | 6.59 |
| CHEMBL107679 | — | — | 1 | 6.58 |
| CHEMBL105160 | — | — | 1 | 6.55 |
| CHEMBL318995 | — | — | 1 | 6.47 |
| CHEMBL105945 | — | — | 1 | 6.40 |
| CHEMBL420662 | — | — | 1 | 6.39 |
| CHEMBL104210 | — | — | 1 | 6.34 |
| CHEMBL104332 | — | — | 1 | 6.17 |
| CHEMBL107444 | — | — | 1 | 6.04 |
| CHEMBL106505 | — | — | 1 | 5.99 |
| CHEMBL104574 | — | — | 1 | 5.86 |
| CHEMBL104804 | — | — | 1 | 5.69 |
| CHEMBL105674 | — | — | 1 | 5.56 |
| CHEMBL104803 | — | — | 1 | 5.51 |
| CHEMBL105593 | — | — | 1 | 5.29 |
| CHEMBL106259 | — | — | 1 | 4.81 |
| CHEMBL107680 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106219 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL320465 | — | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL106224 | — | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL105148 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL104693 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL326450 | — | Ki | = | 151.36 | nM | 6.82 |
| CHEMBL106218 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL105122 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL280220 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL59898 | — | Ki | = | 257.04 | nM | 6.59 |
| CHEMBL107679 | — | Ki | = | 263.03 | nM | 6.58 |
| CHEMBL105160 | — | Ki | = | 281.84 | nM | 6.55 |
| CHEMBL318995 | — | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL105945 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL420662 | — | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL104210 | — | Ki | = | 457.09 | nM | 6.34 |
| CHEMBL104332 | — | Ki | = | 676.08 | nM | 6.17 |
| CHEMBL107444 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL106505 | — | Ki | = | 1023.29 | nM | 5.99 |
| CHEMBL104574 | — | Ki | = | 1380.38 | nM | 5.86 |
| CHEMBL104804 | — | Ki | = | 2041.74 | nM | 5.69 |
| CHEMBL105674 | — | Ki | = | 2754.23 | nM | 5.56 |
| CHEMBL104803 | — | Ki | = | 3090.3 | nM | 5.51 |
| CHEMBL105593 | — | Ki | = | 5128.61 | nM | 5.29 |
| CHEMBL106259 | — | Ki | = | 15488.17 | nM | 4.81 |
| CHEMBL107680 | — | Ki | = | 25703.96 | nM | 4.59 |