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Assay Detail

CHEMBL744773

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human M1 receptor.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Muscarinic acetylcholine receptor M1 (CHEMBL216)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Current and novel approaches to the drug treatment of schizophrenia.
Rowley M, Bristow LJ, Hutson PH.
J Med Chem (2001) 44 : 477 -501
PubMed 11170639 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 4 7.97 8.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL715 OLANZAPINE 4.0 1 8.68
CHEMBL716 QUETIAPINE 4.0 1 7.25
CHEMBL85 RISPERIDONE 4.0 1 -
CHEMBL708 ZIPRASIDONE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL715 OLANZAPINE Ki = 2.1 nM 8.68
CHEMBL716 QUETIAPINE Ki = 56.0 nM 7.25
CHEMBL85 RISPERIDONE Ki > 5000.0 nM -
CHEMBL708 ZIPRASIDONE Ki > 10000.0 nM -