Assay Detail
Binding
CHEMBL744775
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Binding affinity against Muscarinic acetylcholine receptor M1 expressed in CHO-K1 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.95 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71147 | — | — | 1 | 8.55 |
| CHEMBL308566 | — | — | 1 | 8.19 |
| CHEMBL420008 | — | — | 1 | 8.04 |
| CHEMBL421113 | — | — | 1 | 7.59 |
| CHEMBL72551 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71147 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL308566 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL420008 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL421113 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL72551 | — | Ki | = | 42.0 | nM | 7.38 |