Assay Detail
Functional
CHEMBL744838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for in vitro mixed lymphocyte reaction.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A new rational hypothesis for the pharmacophore of the active metabolite of leflunomide, a potent immunosuppressive drug.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.99 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304452 | — | — | 1 | 5.90 |
| CHEMBL64092 | — | — | 1 | 5.78 |
| CHEMBL64492 | — | — | 1 | 5.47 |
| CHEMBL960 | LEFLUNOMIDE | 4.0 | 1 | 5.02 |
| CHEMBL62289 | — | — | 1 | 4.92 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 4.38 |
| CHEMBL61468 | — | — | 1 | 4.34 |
| CHEMBL292494 | — | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304452 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL64092 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL64492 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL62289 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL61468 | — | IC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL292494 | — | IC50 | = | 71600.0 | nM | 4.14 |