Assay Detail
Functional
CHEMBL744887
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In vivo antinociceptive activity by tail-pressure test in mice in the presence of dertorphin II as agonist upon intracerebral administration
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 6.38 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419591 | — | — | 1 | 7.18 |
| CHEMBL332196 | — | — | 1 | 7.05 |
| CHEMBL120091 | — | — | 1 | 6.94 |
| CHEMBL118942 | — | — | 1 | 6.70 |
| CHEMBL409907 | — | — | 1 | 6.52 |
| CHEMBL332371 | — | — | 1 | 6.33 |
| CHEMBL333350 | — | — | 1 | 6.14 |
| CHEMBL433643 | — | — | 1 | 6.12 |
| CHEMBL327036 | — | — | 1 | 5.93 |
| CHEMBL334147 | — | — | 1 | 5.88 |
| CHEMBL331255 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419591 | — | Kd | = | 66.07 | nM | 7.18 |
| CHEMBL332196 | — | Kd | = | 89.13 | nM | 7.05 |
| CHEMBL120091 | — | Kd | = | 114.82 | nM | 6.94 |
| CHEMBL118942 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL409907 | — | Kd | = | 302.0 | nM | 6.52 |
| CHEMBL332371 | — | Kd | = | 467.74 | nM | 6.33 |
| CHEMBL333350 | — | Kd | = | 724.44 | nM | 6.14 |
| CHEMBL433643 | — | Kd | = | 758.58 | nM | 6.12 |
| CHEMBL327036 | — | Kd | = | 1174.9 | nM | 5.93 |
| CHEMBL334147 | — | Kd | = | 1318.26 | nM | 5.88 |
| CHEMBL331255 | — | Kd | = | 3890.45 | nM | 5.41 |