Assay Detail
Functional
CHEMBL744917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro contraction of guinea pig myenteric plexus preparation (mediated by Muscarinic M3 receptor)
3
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL5498) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.92 | 10.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92421 | — | — | 3 | 10.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92421 | — | EC50 | = | 0.045 | nM | 10.35 |
| CHEMBL92421 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL92421 | — | EC50 | = | 16.0 | nM | 7.80 |