Assay Detail
Binding
CHEMBL744921
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The binding affinity was measured as inhibition of binding of [3H]- quinuclidinyl benzilate to Muscarinic acetylcholine receptor M1 in membranes of CHO cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.20 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315428 | — | — | 1 | 6.11 |
| CHEMBL84113 | — | — | 1 | 5.55 |
| CHEMBL313738 | — | — | 1 | 5.16 |
| CHEMBL85190 | — | — | 1 | 5.11 |
| CHEMBL82754 | — | — | 1 | 4.70 |
| CHEMBL314493 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315428 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL84113 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL313738 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL85190 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL82754 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL314493 | — | Ki | = | 27000.0 | nM | 4.57 |