Assay Detail
Binding
CHEMBL744928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]CPP binding to NMDA receptor.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.52 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47277 | — | — | 1 | 7.30 |
| CHEMBL47945 | — | — | 1 | 4.66 |
| CHEMBL9790 | — | — | 1 | 4.60 |
| CHEMBL265301 | — | — | 1 | - |
| CHEMBL295310 | — | — | 1 | - |
| CHEMBL296705 | — | — | 1 | - |
| CHEMBL298469 | — | — | 1 | - |
| CHEMBL48054 | — | — | 1 | - |
| CHEMBL295692 | — | — | 1 | - |
| CHEMBL297648 | — | — | 1 | - |
| CHEMBL295778 | — | — | 1 | - |
| CHEMBL48037 | — | — | 1 | - |
| CHEMBL48038 | — | — | 1 | - |
| CHEMBL45698 | — | — | 1 | - |
| CHEMBL298490 | — | — | 1 | - |
| CHEMBL44059 | — | — | 1 | - |
| CHEMBL297999 | — | — | 1 | - |
| CHEMBL291274 | — | — | 1 | - |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47277 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL47945 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL9790 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL265301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295310 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL296705 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298469 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL48054 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295692 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL297648 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295778 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL48037 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL48038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL45698 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298490 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44059 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL297999 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL291274 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL275040 | KAINIC ACID | IC50 | > | 100000.0 | nM | - |