Assay Detail
Functional
CHEMBL745015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic potency against Muscarinic acetylcholine receptor M3 (10 uM)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL5498) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 5.68 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 6.06 |
| CHEMBL422977 | — | — | 1 | 5.92 |
| CHEMBL134382 | — | — | 1 | 5.89 |
| CHEMBL302179 | — | — | 1 | 5.76 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 5.55 |
| CHEMBL134488 | — | — | 1 | 5.35 |
| CHEMBL132377 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27673 | METHOCTRAMINE | Kd | = | 870.96 | nM | 6.06 |
| CHEMBL422977 | — | Kd | = | 1202.26 | nM | 5.92 |
| CHEMBL134382 | — | Kd | = | 1288.25 | nM | 5.89 |
| CHEMBL302179 | — | Kd | = | 1737.8 | nM | 5.76 |
| CHEMBL11805 | CAPROCTAMINE | Kd | = | 2818.38 | nM | 5.55 |
| CHEMBL134488 | — | Kd | = | 4466.84 | nM | 5.35 |
| CHEMBL132377 | — | Kd | = | 6165.95 | nM | 5.21 |