Assay Detail
Functional
CHEMBL745137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against murine antibody response to T-cell independent B-cell antigen TNP-LPS (type I)
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 4.80 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118468 | — | — | 1 | 5.33 |
| CHEMBL960 | LEFLUNOMIDE | 4.0 | 1 | 5.29 |
| CHEMBL334317 | — | — | 1 | 5.28 |
| CHEMBL118586 | — | — | 1 | 5.24 |
| CHEMBL333344 | — | — | 1 | 5.19 |
| CHEMBL333404 | — | — | 1 | 5.04 |
| CHEMBL119801 | — | — | 1 | 4.94 |
| CHEMBL118645 | — | — | 1 | 4.87 |
| CHEMBL118168 | — | — | 1 | 4.86 |
| CHEMBL116946 | — | — | 1 | 4.84 |
| CHEMBL119193 | — | — | 1 | 4.83 |
| CHEMBL418870 | — | — | 1 | 4.78 |
| CHEMBL331399 | — | — | 1 | 4.77 |
| CHEMBL334117 | — | — | 1 | 4.77 |
| CHEMBL432427 | — | — | 1 | 4.76 |
| CHEMBL119780 | — | — | 1 | 4.72 |
| CHEMBL118395 | — | — | 1 | 4.70 |
| CHEMBL118997 | — | — | 1 | 4.68 |
| CHEMBL118894 | — | — | 1 | 4.67 |
| CHEMBL118489 | — | — | 1 | 4.65 |
| CHEMBL118499 | — | — | 1 | 4.64 |
| CHEMBL118921 | — | — | 1 | 4.62 |
| CHEMBL116206 | — | — | 1 | 4.58 |
| CHEMBL118647 | — | — | 1 | 4.57 |
| CHEMBL332480 | — | — | 1 | 4.55 |
| CHEMBL326960 | — | — | 1 | 4.53 |
| CHEMBL120640 | — | — | 1 | 4.51 |
| CHEMBL445375 | — | — | 1 | 4.50 |
| CHEMBL118125 | — | — | 1 | 4.46 |
| CHEMBL121898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118468 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL334317 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL118586 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL333344 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL333404 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL119801 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL118645 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL118168 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL116946 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL119193 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL418870 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL331399 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL334117 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL432427 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL119780 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL118395 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL118997 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL118894 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL118489 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL118499 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL118921 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL116206 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL118647 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL332480 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL326960 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL120640 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL445375 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL118125 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL160 | CYCLOSPORINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL119697 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL333276 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119564 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL119676 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL330901 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118727 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL118455 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL121898 | — | IC50 | > | 50000.0 | nM | - |