Assay Detail
Functional
CHEMBL745340
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Potency in the Mouse vas deferens (MVD) functional assay was determined in vivo
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.18 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13470 | SNC-80 | — | 1 | 8.10 |
| CHEMBL286053 | — | — | 1 | 7.40 |
| CHEMBL27161 | — | — | 1 | 7.00 |
| CHEMBL24035 | — | — | 1 | 6.20 |
| CHEMBL28443 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13470 | SNC-80 | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL286053 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL27161 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL24035 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL28443 | — | IC50 | < | 10000.0 | nM | - |