Assay Detail
Binding
CHEMBL745475
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In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissue
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.64 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558910 | — | — | 1 | 9.70 |
| CHEMBL2111842 | — | — | 2 | 9.37 |
| CHEMBL127587 | — | — | 2 | 7.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558910 | — | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL2111842 | — | Kd | = | 0.43 | nM | 9.37 |
| CHEMBL2111842 | — | Kd | = | 0.62 | nM | 9.21 |
| CHEMBL127587 | — | Kd | = | 29.6 | nM | 7.53 |
| CHEMBL127587 | — | Kd | = | 41.2 | nM | 7.38 |