Assay Detail
Binding
CHEMBL745478
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Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Myocardium |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Affinity and selectivity of the optical isomers of 3-quinuclidinyl benzilate and related muscarinic antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.75 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558910 | — | — | 1 | 9.64 |
| CHEMBL549577 | — | — | 1 | 9.41 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.15 |
| CHEMBL1788199 | — | — | 1 | 8.23 |
| CHEMBL2115342 | — | — | 1 | 8.16 |
| CHEMBL2115341 | — | — | 1 | 7.43 |
| CHEMBL1788286 | — | — | 1 | 7.13 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.42 |
| CHEMBL2114396 | — | — | 1 | 6.03 |
| CHEMBL2114395 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558910 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL549577 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1788199 | — | Ki | = | 5.83 | nM | 8.23 |
| CHEMBL2115342 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL2115341 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1788286 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 377.0 | nM | 6.42 |
| CHEMBL2114396 | — | Ki | = | 934.0 | nM | 6.03 |
| CHEMBL2114395 | — | Ki | = | 1372.0 | nM | 5.86 |