Assay Detail
Functional
CHEMBL745634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of cAMP in CHO cells expressing human m2 receptor
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.45 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100147 | — | — | 1 | 8.70 |
| CHEMBL98255 | — | — | 1 | 8.05 |
| CHEMBL327269 | — | — | 1 | 7.96 |
| CHEMBL4524086 | — | — | 1 | 7.54 |
| CHEMBL99521 | — | — | 1 | 7.21 |
| CHEMBL99884 | — | — | 1 | 6.86 |
| CHEMBL319109 | — | — | 1 | 6.64 |
| CHEMBL291351 | — | — | 1 | 6.62 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 6.16 |
| CHEMBL60419 | — | — | 1 | 6.11 |
| CHEMBL1169506 | — | — | 1 | 5.97 |
| CHEMBL100163 | — | — | 1 | 5.96 |
| CHEMBL4524085 | — | — | 1 | 5.65 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 5.00 |
| CHEMBL81878 | — | — | 1 | 4.55 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 4.20 |
| CHEMBL316625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100147 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL98255 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL327269 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4524086 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL99521 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL99884 | — | EC50 | = | 139.0 | nM | 6.86 |
| CHEMBL319109 | — | EC50 | = | 227.0 | nM | 6.64 |
| CHEMBL291351 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL14 | CARBACHOL | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL60419 | — | EC50 | = | 779.0 | nM | 6.11 |
| CHEMBL1169506 | — | EC50 | = | 1075.0 | nM | 5.97 |
| CHEMBL100163 | — | EC50 | = | 1096.0 | nM | 5.96 |
| CHEMBL4524085 | — | EC50 | = | 2253.0 | nM | 5.65 |
| CHEMBL7303 | ARECOLINE | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL81878 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL550 | PILOCARPINE | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL316625 | — | EC50 | > | 10000.0 | nM | - |