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Compound Detail

CHEMBL316625

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C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CCC[C@H]1C2

Basic Information

ChEMBL ID CHEMBL316625
Phase Preclinical
Structure Type MOL
InChI Key HCABSDMEPTYQBN-JKSUJKDBSA-N
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

341.5
MW (Da)
3.49
ALogP
5
HBA
0
HBD
29.0
PSA (Ų)
0.63
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H19N3S2
MW 341.51
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.39

Activity Summary

EC50 1 meas. best 9.0
IC50 1 meas. best 6.44

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
EC50 9.0 9.0 1.0 1
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 6.44 6.44 363.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9873644 10.1016/s0960-894x(98)00509-5 Muscarinic acetylcholine receptor M1 3
9873644 10.1016/s0960-894x(98)00509-5 Muscarinic acetylcholine receptor M2 2
9873644 10.1016/s0960-894x(98)00509-5 Muscarinic acetylcholine receptor 1
9873644 10.1016/s0960-894x(98)00509-5 Unchecked 1

Data from ChEMBL 36 via Core Engine