Assay Detail
Functional
CHEMBL745653
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Percentage increase in lifespan of drug-related tumor bearing animals when heated at the optimal dose and tested in murine leukemia P388 cell lines.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of DNA-targeted spatially separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.51 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313191 | — | — | 1 | 4.60 |
| CHEMBL83806 | — | — | 1 | 4.58 |
| CHEMBL278918 | — | — | 1 | 4.44 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 4.43 |
| CHEMBL314685 | — | — | 1 | - |
| CHEMBL79723 | — | — | 1 | - |
| CHEMBL273595 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313191 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL83806 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL278918 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL314685 | — | IC50 | = | - | nM | - |
| CHEMBL79723 | — | IC50 | = | - | nM | - |
| CHEMBL273595 | — | IC50 | = | - | nM | - |