Assay Detail
Binding
CHEMBL745663
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Displacement of [3H]pirenzepine from muscarinic acetylcholine receptor M1 in rat cortex homogenates
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Muscarinic receptor binding profile of para-substituted caramiphen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.42 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558910 | — | — | 1 | 9.82 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.59 |
| CHEMBL61946 | CARAMIPHEN | 2.0 | 1 | 8.92 |
| CHEMBL544107 | — | — | 1 | 8.68 |
| CHEMBL1123 | DICYCLOMINE | 4.0 | 1 | 8.61 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 8.28 |
| CHEMBL543382 | — | — | 1 | 8.26 |
| CHEMBL553755 | — | — | 1 | 8.09 |
| CHEMBL542915 | — | — | 1 | 7.84 |
| CHEMBL538266 | — | — | 1 | 7.70 |
| CHEMBL542914 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558910 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL61946 | CARAMIPHEN | Ki | = | 1.21 | nM | 8.92 |
| CHEMBL544107 | — | Ki | = | 2.11 | nM | 8.68 |
| CHEMBL1123 | DICYCLOMINE | Ki | = | 2.47 | nM | 8.61 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 5.21 | nM | 8.28 |
| CHEMBL543382 | — | Ki | = | 5.52 | nM | 8.26 |
| CHEMBL553755 | — | Ki | = | 8.12 | nM | 8.09 |
| CHEMBL542915 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL538266 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL542914 | — | Ki | = | 151.0 | nM | 6.82 |