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Compound Detail

CHEMBL542915

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CCN(CC)CCOC(=O)C1(c2ccc(-n3cnnn3)cc2)CCCC1.Cl

Basic Information

ChEMBL ID CHEMBL542915
Phase Preclinical
Structure Type MOL
InChI Key CIJKNSKFLKAZIG-UHFFFAOYSA-N
Parent Compound CHEMBL1191773
Active Moiety CHEMBL1191773
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

357.5
MW (Da)
2.36
ALogP
7
HBA
0
HBD
73.1
PSA (Ų)
0.68
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H28ClN5O2
MW 393.92
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -1.88

Activity Summary

Ki 2 meas. best 7.84

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
Ki 7.84 7.84 14.5 1
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 6.37 6.37 432.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1920350 10.1021/jm00114a005 Muscarinic acetylcholine receptor M1 1
1920350 10.1021/jm00114a005 Muscarinic acetylcholine receptor M2 1
1920350 10.1021/jm00114a005 Muscarinic receptor M1 and M2 1

Data from ChEMBL 36 via Core Engine