Assay Detail
Binding
CHEMBL744906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenates
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Heart |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Muscarinic receptor binding profile of para-substituted caramiphen analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.33 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558910 | — | — | 1 | 10.52 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.12 |
| CHEMBL61946 | CARAMIPHEN | 2.0 | 1 | 7.50 |
| CHEMBL1123 | DICYCLOMINE | 4.0 | 1 | 7.33 |
| CHEMBL538266 | — | — | 1 | 6.94 |
| CHEMBL544107 | — | — | 1 | 6.91 |
| CHEMBL553755 | — | — | 1 | 6.67 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.57 |
| CHEMBL543382 | — | — | 1 | 6.41 |
| CHEMBL542915 | — | — | 1 | 6.37 |
| CHEMBL542914 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558910 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL61946 | CARAMIPHEN | Ki | = | 31.7 | nM | 7.50 |
| CHEMBL1123 | DICYCLOMINE | Ki | = | 47.3 | nM | 7.33 |
| CHEMBL538266 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL544107 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL553755 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL543382 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL542915 | — | Ki | = | 432.0 | nM | 6.37 |
| CHEMBL542914 | — | Ki | = | 551.0 | nM | 6.26 |