Assay Detail
Binding
CHEMBL745680
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Displacement of [3H]pirenzepine from M1 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.80 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL167004 | — | — | 1 | 6.82 |
| CHEMBL169469 | — | — | 1 | 6.29 |
| CHEMBL169695 | — | — | 1 | 6.06 |
| CHEMBL354482 | — | — | 1 | 5.96 |
| CHEMBL166599 | — | — | 1 | 5.92 |
| CHEMBL166991 | — | — | 1 | 5.72 |
| CHEMBL166935 | — | — | 1 | 5.60 |
| CHEMBL166697 | — | — | 1 | 5.58 |
| CHEMBL170552 | — | — | 1 | 5.42 |
| CHEMBL299294 | — | — | 1 | 5.21 |
| CHEMBL168496 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL167004 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL169469 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL169695 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL354482 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL166599 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL166991 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL166935 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL166697 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL170552 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL299294 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL168496 | — | Ki | = | 6500.0 | nM | 5.19 |