Assay Detail
Functional
CHEMBL745685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1.
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | A9L |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.76 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340435 | — | — | 1 | 9.00 |
| CHEMBL126846 | — | — | 2 | 8.72 |
| CHEMBL433867 | — | — | 1 | 7.65 |
| CHEMBL341242 | — | — | 1 | 6.99 |
| CHEMBL125732 | — | — | 2 | 6.87 |
| CHEMBL129764 | — | — | 1 | 6.78 |
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 6.70 |
| CHEMBL126237 | — | — | 1 | 6.65 |
| CHEMBL126332 | — | — | 1 | 6.59 |
| CHEMBL337925 | — | — | 1 | 6.37 |
| CHEMBL20835 | ACECLIDINE | 3.0 | 1 | 5.35 |
| CHEMBL129474 | — | — | 1 | 5.31 |
| CHEMBL340021 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340435 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL126846 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL433867 | — | EC50 | = | 22.3 | nM | 7.65 |
| CHEMBL341242 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL125732 | — | EC50 | = | 135.8 | nM | 6.87 |
| CHEMBL126846 | — | EC50 | = | 161.7 | nM | 6.79 |
| CHEMBL129764 | — | EC50 | = | 164.8 | nM | 6.78 |
| CHEMBL21536 | XANOMELINE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL126237 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL126332 | — | EC50 | = | 258.9 | nM | 6.59 |
| CHEMBL337925 | — | EC50 | = | 430.9 | nM | 6.37 |
| CHEMBL125732 | — | EC50 | = | 433.3 | nM | 6.36 |
| CHEMBL20835 | ACECLIDINE | EC50 | = | 4466.0 | nM | 5.35 |
| CHEMBL129474 | — | EC50 | = | 4867.0 | nM | 5.31 |
| CHEMBL340021 | — | EC50 | = | 6202.0 | nM | 5.21 |