Assay Detail
Binding
CHEMBL745743
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human muscarinic M1 receptor in CHO-KI cells using [3H]- QNB as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-KI |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.58 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355854 | — | — | 1 | 8.37 |
| CHEMBL277642 | HIMBACINE | — | 1 | 8.35 |
| CHEMBL354636 | — | — | 1 | 7.42 |
| CHEMBL353311 | — | — | 1 | 6.87 |
| CHEMBL170977 | — | — | 1 | 6.75 |
| CHEMBL352618 | — | — | 1 | 6.65 |
| CHEMBL352756 | — | — | 1 | 6.52 |
| CHEMBL172272 | — | — | 1 | 6.51 |
| CHEMBL426032 | — | — | 1 | 6.47 |
| CHEMBL355193 | — | — | 1 | 6.45 |
| CHEMBL355475 | — | — | 1 | 6.42 |
| CHEMBL366819 | — | — | 1 | 6.40 |
| CHEMBL352596 | — | — | 1 | 6.38 |
| CHEMBL170205 | — | — | 1 | 6.37 |
| CHEMBL366640 | — | — | 1 | 6.35 |
| CHEMBL171520 | — | — | 1 | 6.33 |
| CHEMBL172969 | — | — | 1 | 6.26 |
| CHEMBL170922 | — | — | 1 | 6.24 |
| CHEMBL173950 | — | — | 1 | 6.24 |
| CHEMBL354934 | — | — | 1 | 6.22 |
| CHEMBL368990 | — | — | 1 | 6.07 |
| CHEMBL423438 | — | — | 1 | 5.87 |
| CHEMBL172646 | — | — | 1 | 5.81 |
| CHEMBL445134 | — | — | 1 | - |
| CHEMBL173155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355854 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL277642 | HIMBACINE | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL354636 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL353311 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL170977 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL352618 | — | Ki | = | 222.0 | nM | 6.65 |
| CHEMBL352756 | — | Ki | = | 304.0 | nM | 6.52 |
| CHEMBL172272 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL426032 | — | Ki | = | 341.0 | nM | 6.47 |
| CHEMBL355193 | — | Ki | = | 353.0 | nM | 6.45 |
| CHEMBL355475 | — | Ki | = | 376.0 | nM | 6.42 |
| CHEMBL366819 | — | Ki | = | 399.0 | nM | 6.40 |
| CHEMBL352596 | — | Ki | = | 416.0 | nM | 6.38 |
| CHEMBL170205 | — | Ki | = | 427.0 | nM | 6.37 |
| CHEMBL366640 | — | Ki | = | 445.0 | nM | 6.35 |
| CHEMBL171520 | — | Ki | = | 464.0 | nM | 6.33 |
| CHEMBL172969 | — | Ki | = | 554.0 | nM | 6.26 |
| CHEMBL170922 | — | Ki | = | 579.0 | nM | 6.24 |
| CHEMBL173950 | — | Ki | = | 581.0 | nM | 6.24 |
| CHEMBL354934 | — | Ki | = | 601.0 | nM | 6.22 |
| CHEMBL368990 | — | Ki | = | 857.0 | nM | 6.07 |
| CHEMBL423438 | — | Ki | = | 1361.0 | nM | 5.87 |
| CHEMBL172646 | — | Ki | = | 1533.0 | nM | 5.81 |
| CHEMBL445134 | — | Ki | > | 900.0 | nM | - |
| CHEMBL173155 | — | Ki | > | 420.0 | nM | - |