Assay Detail
Functional
CHEMBL746008
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The inhibitory concentration activity was measured on electrically induced contraction of the mouse vas deferens (MVD)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.84 | 10.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433978 | — | — | 1 | 10.42 |
| CHEMBL177647 | — | — | 1 | 10.15 |
| CHEMBL175116 | — | — | 1 | 10.09 |
| CHEMBL369499 | — | — | 1 | 10.05 |
| CHEMBL296603 | DELTORPHINE II | — | 1 | 9.68 |
| CHEMBL426776 | — | — | 1 | 9.57 |
| CHEMBL281140 | — | — | 1 | 9.49 |
| CHEMBL433720 | — | — | 1 | 9.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433978 | — | IC50 | = | 0.038 | nM | 10.42 |
| CHEMBL177647 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL175116 | — | IC50 | = | 0.082 | nM | 10.09 |
| CHEMBL369499 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL296603 | DELTORPHINE II | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL426776 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL281140 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL433720 | — | IC50 | = | 0.5 | nM | 9.30 |