Assay Detail
Binding
CHEMBL746423
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Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | A9L |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL3733) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 4.91 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.57 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | — | 1 | 6.16 |
| CHEMBL277014 | — | — | 1 | 5.27 |
| CHEMBL21536 | XANOMELINE | 4.0 | 1 | 5.24 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 5.16 |
| CHEMBL12378 | — | — | 1 | 4.92 |
| CHEMBL416736 | — | — | 1 | 4.92 |
| CHEMBL281411 | — | — | 1 | 4.85 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 4.57 |
| CHEMBL542065 | — | — | 1 | 4.48 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.40 |
| CHEMBL553602 | — | — | 1 | 4.39 |
| CHEMBL541398 | — | — | 1 | 4.36 |
| CHEMBL542064 | — | — | 1 | 4.30 |
| CHEMBL543030 | — | — | 1 | 4.10 |
| CHEMBL542561 | — | — | 1 | - |
| CHEMBL538467 | — | — | 1 | - |
| CHEMBL557795 | — | — | 1 | - |
| CHEMBL538224 | — | — | 1 | - |
| CHEMBL542559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL23957 | OXOTREMORINE METHIODIDE | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL277014 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL21536 | XANOMELINE | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL550 | PILOCARPINE | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL12378 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL416736 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL281411 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL7303 | ARECOLINE | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL542065 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL14 | CARBACHOL | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL553602 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL541398 | — | EC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL542064 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL543030 | — | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL542561 | — | EC50 | = | 300000.0 | nM | - |
| CHEMBL538467 | — | EC50 | = | 200000.0 | nM | - |
| CHEMBL557795 | — | EC50 | = | 116000.0 | nM | - |
| CHEMBL538224 | — | EC50 | = | 160000.0 | nM | - |
| CHEMBL542559 | — | EC50 | = | 560000.0 | nM | - |