Assay Detail
Binding
CHEMBL746549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration which causes 50% reduction in receptor binding affinity against N-methyl-D-aspartate glutamate receptor (NMDA) using [3H]CPP
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.64 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178058 | — | — | 1 | 4.85 |
| CHEMBL367027 | — | — | 1 | 4.70 |
| CHEMBL368556 | — | — | 1 | 4.38 |
| CHEMBL176855 | — | — | 1 | - |
| CHEMBL9698 | — | — | 1 | - |
| CHEMBL367189 | — | — | 1 | - |
| CHEMBL88184 | — | — | 1 | - |
| CHEMBL368858 | — | — | 1 | - |
| CHEMBL174625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178058 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL367027 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL368556 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL176855 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL9698 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL367189 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL88184 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL368858 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL174625 | — | IC50 | > | 100000.0 | nM | - |