Assay Detail
Functional
CHEMBL746600
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory effect in isolated tissues of Mouse vas deferens (MVD).
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.93 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121211 | — | — | 2 | 10.00 |
| CHEMBL333410 | — | — | 1 | 9.23 |
| CHEMBL338510 | — | — | 1 | 8.94 |
| CHEMBL121403 | — | — | 1 | 8.79 |
| CHEMBL121494 | — | — | 1 | 8.31 |
| CHEMBL121060 | — | — | 1 | - |
| CHEMBL435380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121211 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL333410 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL338510 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL121403 | — | IC50 | = | 1.64 | nM | 8.79 |
| CHEMBL121211 | — | IC50 | = | 4.87 | nM | 8.31 |
| CHEMBL121494 | — | IC50 | = | 4.87 | nM | 8.31 |
| CHEMBL121060 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL435380 | — | IC50 | > | 1000.0 | nM | - |