Assay Detail
Functional
CHEMBL747078
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellularly applied glutamate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2C (CHEMBL401) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Oxindole N-Methyl-D-Aspartate (NMDA) antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.72 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366809 | — | — | 1 | 7.40 |
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 7.26 |
| CHEMBL427116 | — | — | 1 | 6.96 |
| CHEMBL172807 | — | — | 1 | 6.64 |
| CHEMBL49623 | (R,S)-IFENPRODIL | — | 1 | 6.58 |
| CHEMBL173092 | — | — | 1 | 6.22 |
| CHEMBL28564 | ELIPRODIL | 2.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366809 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL319706 | (S)-IFENPRODIL | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL427116 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL172807 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL49623 | (R,S)-IFENPRODIL | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL173092 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL28564 | ELIPRODIL | IC50 | = | 1000.0 | nM | 6.00 |