Assay Detail
Binding
CHEMBL747082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for binding affinity against glycine site of NMDA receptor using [3H]glycine as a radioligand.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2C (CHEMBL401) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Pyrrolylquinoxalinediones: A new class of AMPA receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.13 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330175 | — | — | 1 | 5.92 |
| CHEMBL12448 | — | — | 1 | 5.10 |
| CHEMBL12730 | — | — | 1 | 5.00 |
| CHEMBL222519 | NBQX | — | 1 | 4.48 |
| CHEMBL305534 | — | — | 1 | - |
| CHEMBL99012 | — | — | 1 | - |
| CHEMBL268284 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330175 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL12448 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL12730 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL222519 | NBQX | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL305534 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL99012 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL268284 | — | Ki | > | 25000.0 | nM | - |