Compound Detail
CHEMBL330175
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Basic Information
| ChEMBL ID | CHEMBL330175 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YRGSHIFWTACIDR-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
367.3
MW (Da)
1.97
ALogP
5
HBA
2
HBD
97.1
PSA (Ų)
0.69
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2096617 | Ki | 6.41 | 6.41 | 390.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2C CHEMBL401 | Ki | 5.92 | 5.92 | 1200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 390.0 | nM | 6.41 | Compound was tested for binding affinity against Ionotropic glutamate receptor A... | - |
| Glutamate receptor ionotropic, NMDA 2C | Ki | = | 1200.0 | nM | 5.92 | Compound was tested for binding affinity against glycine site of NMDA receptor u... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(96)00534-3 | Mus musculus | 2 |
| - | 10.1016/S0960-894X(96)00534-3 | Glutamate receptor ionotropic, AMPA | 1 |
| - | 10.1016/S0960-894X(96)00534-3 | Glutamate receptor ionotropic, NMDA 2C | 1 |
| - | 10.1016/S0960-894X(96)00534-3 | Glutamate receptor ionotropic kainate | 1 |
Data from ChEMBL 36 via Core Engine