Assay Detail
Functional
CHEMBL747119
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Antimuscarinic activity on the acetylcholine-induced inhibition of contraction of guinea pig ileum which has M2 muscarinic receptor subtype.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.12 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.70 |
| CHEMBL26505 | APROFENE | 2.0 | 1 | 8.50 |
| CHEMBL37372 | — | — | 1 | 7.20 |
| CHEMBL39342 | — | — | 1 | 5.70 |
| CHEMBL288482 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL26505 | APROFENE | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL37372 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL39342 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL288482 | — | Kd | = | 3162.28 | nM | 5.50 |