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Compound Detail

CHEMBL39342

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CCN(CC)CCOC(=O)C(C)(c1ccc(O)cc1)c1ccc(O)cc1

Basic Information

ChEMBL ID CHEMBL39342
Phase Preclinical
Structure Type MOL
InChI Key OPAKKEAZIKVTMS-UHFFFAOYSA-N
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

357.4
MW (Da)
3.29
ALogP
5
HBA
2
HBD
70.0
PSA (Ų)
0.71
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H27NO4
MW 357.45
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.29

Activity Summary

Ki 2 meas. best 5.68
Kd 1 meas. best 5.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Kd 5.7 5.7 1995.3 1
Muscarinic acetylcholine receptor M1
CHEMBL2672
Ki 5.68 5.68 2100.0 1
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 5.31 5.31 4900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2738887 10.1021/jm00127a020 Muscarinic acetylcholine receptor M2 3
2738887 10.1021/jm00127a020 Muscarinic acetylcholine receptor M1 1

Data from ChEMBL 36 via Core Engine