Assay Detail
Binding
CHEMBL745753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of carbachol-induced release of alpha-amylase from pancreatic acinar cells from that of rat ileum contained the M2 receptor subtypes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Ileum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.35 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.80 |
| CHEMBL26505 | APROFENE | 2.0 | 1 | 8.77 |
| CHEMBL37372 | — | — | 1 | 8.25 |
| CHEMBL288482 | — | — | 1 | 5.62 |
| CHEMBL39342 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL26505 | APROFENE | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL37372 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL288482 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL39342 | — | Ki | = | 4900.0 | nM | 5.31 |