Assay Detail
Binding
CHEMBL747248
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Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.92 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.62 |
| CHEMBL36583 | — | — | 1 | 7.58 |
| CHEMBL26505 | APROFENE | 2.0 | 1 | 7.29 |
| CHEMBL37372 | — | — | 1 | 7.00 |
| CHEMBL416974 | — | — | 1 | 6.82 |
| CHEMBL39342 | — | — | 1 | 5.68 |
| CHEMBL288482 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL36583 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL26505 | APROFENE | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL37372 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL416974 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL39342 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL288482 | — | Ki | = | 3400.0 | nM | 5.47 |