Assay Detail
Binding
CHEMBL747395
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Compound was evaluated for its binding affinity against muscarinic acetylcholine receptor M1 in guinea pig cerebral cortex using (-)-[3H]-QNB as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Analogues of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.09 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38756 | — | — | 1 | 5.54 |
| CHEMBL289894 | — | — | 1 | 5.20 |
| CHEMBL291280 | — | — | 1 | 5.20 |
| CHEMBL39922 | — | — | 1 | 5.03 |
| CHEMBL287834 | — | — | 1 | 4.82 |
| CHEMBL290715 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38756 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL289894 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL291280 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL39922 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL287834 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL290715 | — | Ki | = | 19000.0 | nM | 4.72 |