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Assay Detail

CHEMBL747398

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cricetulus griseus
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Muscarinic acetylcholine receptor M1 (CHEMBL216)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Crystal, solution, and molecular modeling structural properties and muscarinic antagonist activity of azaprophen.
Carroll FI, Abraham P, Mascarella SW, Singh P, Moreland CG, Sankar SS, Kwon YW, Triggle DJ.
J Med Chem (1991) 34 : 1436 -1440
PubMed 2016720 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.48 9.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL517712 ATROPINE 4.0 1 9.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL517712 ATROPINE Ki = 0.329 nM 9.48