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Assay Detail

CHEMBL747467

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Binding
Ability to displace [3H]QNB from HM1 receptor binding to acetylcholine was evaluated by ligand inhibition assay
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Muscarinic acetylcholine receptor M1 (CHEMBL216)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

First fatty acylated dipeptides to affect muscarinic receptor ligand binding.
Krishnan V, Pham WN, Messer WS, Peseckis SM.
Bioorg Med Chem Lett (1999) 9 : 3363 -3368
PubMed 10612600 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 8.52 10.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL112297 2 10.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL112297 Ki = 0.01288 nM 10.89
CHEMBL112297 Ki = 707.95 nM 6.15