Assay Detail
Binding
CHEMBL747490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards NMDA receptor by displacement of [3H]CGP-39653 radioligand.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.90 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.70 |
| CHEMBL86273 | — | — | 1 | 6.31 |
| CHEMBL82172 | — | — | 1 | 5.52 |
| CHEMBL82935 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL86273 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL82172 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL82935 | — | Ki | = | 9000.0 | nM | 5.05 |