Assay Detail
Binding
CHEMBL747590
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Binding affinity against muscarinic acetylcholine receptor from rat brain crude membrane, using [3H]OXO-M (oxotremorine) as the radioligand.
48
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In vitro muscarinic activity of spiromuscarones and related analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 6.64 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290723 | — | — | 1 | 9.12 |
| CHEMBL43191 | — | — | 1 | 8.30 |
| CHEMBL40121 | — | — | 1 | 8.15 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 8.13 |
| CHEMBL289657 | — | — | 2 | 7.85 |
| CHEMBL20835 | ACECLIDINE | 3.0 | 1 | 7.80 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 7.58 |
| CHEMBL2114433 | — | — | 1 | 7.57 |
| CHEMBL40032 | — | — | 1 | 7.54 |
| CHEMBL448736 | — | — | 1 | 7.52 |
| CHEMBL39564 | — | — | 1 | 7.50 |
| CHEMBL288113 | — | — | 1 | 7.46 |
| CHEMBL40063 | — | — | 1 | 7.44 |
| CHEMBL1794944 | — | — | 1 | 7.11 |
| CHEMBL1794942 | — | — | 1 | 7.05 |
| CHEMBL290208 | — | — | 2 | 7.05 |
| CHEMBL1794941 | — | — | 1 | 6.89 |
| CHEMBL1794939 | — | — | 1 | 6.72 |
| CHEMBL38540 | — | — | 1 | 6.72 |
| CHEMBL1794938 | — | — | 1 | 6.52 |
| CHEMBL542350 | — | — | 1 | 6.47 |
| CHEMBL417707 | — | — | 1 | 6.40 |
| CHEMBL40803 | — | — | 1 | 6.40 |
| CHEMBL553369 | — | — | 1 | 6.34 |
| CHEMBL1744377 | — | — | 1 | 6.26 |
| CHEMBL287747 | — | — | 1 | 6.26 |
| CHEMBL543292 | — | — | 1 | 6.19 |
| CHEMBL41879 | — | — | 1 | 6.19 |
| CHEMBL1794943 | — | — | 1 | 6.10 |
| CHEMBL1794937 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290723 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL43191 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL40121 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL7303 | ARECOLINE | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL289657 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL20835 | ACECLIDINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL550 | PILOCARPINE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL2114433 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL40032 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL448736 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL39564 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL288113 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL40063 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL289657 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL1794944 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL290208 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL1794942 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL1794941 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL1794939 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL38540 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL1794938 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL290208 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL542350 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL40803 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL417707 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL553369 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL1744377 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL287747 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL543292 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL41879 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL1794943 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL1794937 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL289139 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL41524 | — | Ki | = | 1470.0 | nM | 5.83 |
| CHEMBL39291 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL287943 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL1794940 | — | Ki | = | 1810.0 | nM | 5.74 |
| CHEMBL288465 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL442154 | — | Ki | = | 2710.0 | nM | 5.57 |
| CHEMBL38519 | — | Ki | = | 3030.0 | nM | 5.52 |
| CHEMBL39486 | — | Ki | = | 3070.0 | nM | 5.51 |
| CHEMBL288717 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL289552 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL555094 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL553322 | — | Ki | = | 8540.0 | nM | 5.07 |
| CHEMBL40045 | — | Ki | = | 175000.0 | nM | - |
| CHEMBL290501 | — | Ki | = | 330000.0 | nM | - |
| CHEMBL40524 | — | Ki | = | 1000000.0 | nM | - |