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Compound Detail

CHEMBL288113

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CC1OCC2(CCN(C)CC2)O1

Basic Information

ChEMBL ID CHEMBL288113
Phase Preclinical
Structure Type MOL
InChI Key VHBBMEXIWWKUNY-UHFFFAOYSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

171.2
MW (Da)
0.84
ALogP
3
HBA
0
HBD
21.7
PSA (Ų)
0.54
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H17NO2
MW 171.24
Aromatic Rings 0
Heavy Atoms 12
NP-Likeness 0.81

Activity Summary

Ki 4 meas. best 7.46

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 7.46 7.46 35.0 1
Muscarinic acetylcholine receptor M1
CHEMBL276
Ki 7.0 6.12 100.0 2
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 4.6 4.6 25100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80537-5 Muscarinic acetylcholine receptor M1 6
7739014 10.1021/jm00009a016 Muscarinic acetylcholine receptor 3
3339620 10.1021/jm00397a039 Muscarinic acetylcholine receptor 2
3339620 10.1021/jm00397a039 Unchecked 1
7739014 10.1021/jm00009a016 Unchecked 1

Data from ChEMBL 36 via Core Engine