Assay Detail
Binding
CHEMBL747589
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Binding affinity against muscarinic acetylcholine receptor from rat brain crude membrane, using [3H]-NMS (N-Methylscopolamine) as the radioligand.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
In vitro muscarinic activity of spiromuscarones and related analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 4.90 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290723 | — | — | 1 | 6.16 |
| CHEMBL1794941 | — | — | 1 | 5.83 |
| CHEMBL1794940 | — | — | 1 | 5.83 |
| CHEMBL40032 | — | — | 1 | 5.79 |
| CHEMBL40063 | — | — | 1 | 5.59 |
| CHEMBL40121 | — | — | 1 | 5.57 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 5.43 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 5.15 |
| CHEMBL20835 | ACECLIDINE | 3.0 | 1 | 5.08 |
| CHEMBL288113 | — | — | 1 | 4.60 |
| CHEMBL290501 | — | — | 1 | 4.52 |
| CHEMBL288465 | — | — | 1 | 4.48 |
| CHEMBL1794937 | — | — | 1 | 4.47 |
| CHEMBL1794938 | — | — | 1 | 4.42 |
| CHEMBL41524 | — | — | 1 | 4.40 |
| CHEMBL1794939 | — | — | 1 | 4.35 |
| CHEMBL543292 | — | — | 1 | 4.15 |
| CHEMBL39564 | — | — | 1 | 4.08 |
| CHEMBL39486 | — | — | 1 | 4.06 |
| CHEMBL288717 | — | — | 1 | 4.01 |
| CHEMBL442154 | — | — | 1 | - |
| CHEMBL555094 | — | — | 1 | - |
| CHEMBL553322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290723 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL1794941 | — | Ki | = | 1470.0 | nM | 5.83 |
| CHEMBL1794940 | — | Ki | = | 1470.0 | nM | 5.83 |
| CHEMBL40032 | — | Ki | = | 1630.0 | nM | 5.79 |
| CHEMBL40063 | — | Ki | = | 2580.0 | nM | 5.59 |
| CHEMBL40121 | — | Ki | = | 2680.0 | nM | 5.57 |
| CHEMBL550 | PILOCARPINE | Ki | = | 3670.0 | nM | 5.43 |
| CHEMBL7303 | ARECOLINE | Ki | = | 7120.0 | nM | 5.15 |
| CHEMBL20835 | ACECLIDINE | Ki | = | 8260.0 | nM | 5.08 |
| CHEMBL288113 | — | Ki | = | 25100.0 | nM | 4.60 |
| CHEMBL290501 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL288465 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL1794937 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL1794938 | — | Ki | = | 38100.0 | nM | 4.42 |
| CHEMBL41524 | — | Ki | = | 39900.0 | nM | 4.40 |
| CHEMBL1794939 | — | Ki | = | 44800.0 | nM | 4.35 |
| CHEMBL543292 | — | Ki | = | 71000.0 | nM | 4.15 |
| CHEMBL39564 | — | Ki | = | 83300.0 | nM | 4.08 |
| CHEMBL39486 | — | Ki | = | 87400.0 | nM | 4.06 |
| CHEMBL288717 | — | Ki | = | 98700.0 | nM | 4.01 |
| CHEMBL442154 | — | Ki | = | 141000.0 | nM | - |
| CHEMBL555094 | — | Ki | = | 430000.0 | nM | - |
| CHEMBL553322 | — | Ki | = | 734000.0 | nM | - |