Assay Detail
Binding
CHEMBL747619
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Binding affinity against Muscarinic acetylcholine receptor M2
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.89 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2114068 | — | — | 1 | 10.52 |
| CHEMBL2115128 | — | — | 1 | 10.24 |
| CHEMBL71124 | — | — | 1 | 9.85 |
| CHEMBL71147 | — | — | 1 | 9.77 |
| CHEMBL70828 | — | — | 1 | 9.43 |
| CHEMBL307810 | — | — | 1 | 9.00 |
| CHEMBL69595 | — | — | 1 | 8.89 |
| CHEMBL2111540 | — | — | 1 | 8.56 |
| CHEMBL71531 | — | — | 1 | 8.51 |
| CHEMBL2114067 | — | — | 1 | 8.45 |
| CHEMBL2115126 | — | — | 1 | 8.15 |
| CHEMBL71971 | — | — | 1 | 8.14 |
| CHEMBL2114064 | — | — | 1 | 8.12 |
| CHEMBL2115127 | — | — | 1 | 7.97 |
| CHEMBL2114066 | — | — | 1 | 7.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2114068 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL2115128 | — | Ki | = | 0.057 | nM | 10.24 |
| CHEMBL71124 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL71147 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL70828 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL307810 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL69595 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2111540 | — | Ki | = | 2.78 | nM | 8.56 |
| CHEMBL71531 | — | Ki | = | 3.07 | nM | 8.51 |
| CHEMBL2114067 | — | Ki | = | 3.58 | nM | 8.45 |
| CHEMBL2115126 | — | Ki | = | 7.14 | nM | 8.15 |
| CHEMBL71971 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL2114064 | — | Ki | = | 7.67 | nM | 8.12 |
| CHEMBL2115127 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL2114066 | — | Ki | = | 17.3 | nM | 7.76 |