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Compound Detail

CHEMBL69595

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COc1ccc(S(=O)(=O)c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1

Basic Information

ChEMBL ID CHEMBL69595
Phase Preclinical
Structure Type MOL
InChI Key QDDPQJCCXUPHKY-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

452.6
MW (Da)
5.18
ALogP
5
HBA
0
HBD
70.4
PSA (Ų)
0.60
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H32N2O3S
MW 452.62
Aromatic Rings 2
Heavy Atoms 32
NP-Likeness -0.69

Activity Summary

Ki 2 meas. best 8.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 8.89 8.89 1.3 1
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 7.79 7.79 16.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11012031 10.1016/s0960-894x(00)00437-6 Muscarinic acetylcholine receptor M1 1
11012031 10.1016/s0960-894x(00)00437-6 Muscarinic acetylcholine receptor M2 1
11012031 10.1016/s0960-894x(00)00437-6 Muscarinic acetylcholine receptor M3 1
11012031 10.1016/s0960-894x(00)00437-6 Muscarinic acetylcholine receptor M4 1
11012031 10.1016/s0960-894x(00)00437-6 Muscarinic acetylcholine receptor M5 1

Data from ChEMBL 36 via Core Engine