Assay Detail
Binding
CHEMBL747707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]naloxone from human mu opioid receptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
8-acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.75 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78156 | — | — | 1 | 8.40 |
| CHEMBL355202 | — | — | 1 | 8.40 |
| CHEMBL281274 | — | — | 1 | 8.20 |
| CHEMBL77877 | — | — | 1 | 8.10 |
| CHEMBL308522 | — | — | 1 | 8.00 |
| CHEMBL1907858 | — | — | 1 | 7.90 |
| CHEMBL419272 | — | — | 1 | 7.90 |
| CHEMBL312021 | — | — | 1 | 7.70 |
| CHEMBL78163 | — | — | 1 | 7.70 |
| CHEMBL306150 | — | — | 1 | 7.60 |
| CHEMBL77324 | — | — | 1 | 7.50 |
| CHEMBL311185 | — | — | 1 | 7.40 |
| CHEMBL75676 | — | — | 1 | 7.30 |
| CHEMBL431002 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78156 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL355202 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL281274 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL77877 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL308522 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1907858 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL419272 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL312021 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL78163 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL306150 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL77324 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL311185 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL75676 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL431002 | — | Ki | = | 398.11 | nM | 6.40 |