Assay Detail
Binding
CHEMBL747775
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Muscarinic receptor M1 in rat brain using [3H]-PZ (pirenzepine) radioligand at a concentration of 1 nM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.31 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275104 | — | — | 1 | 7.11 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 7.00 |
| CHEMBL8610 | — | — | 1 | 6.38 |
| CHEMBL274329 | — | — | 1 | 5.89 |
| CHEMBL8510 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275104 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL8610 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL274329 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL8510 | — | IC50 | = | 7100.0 | nM | 5.15 |