Compound Detail
CHEMBL8610
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Basic Information
| ChEMBL ID | CHEMBL8610 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JBWNQBYECBRHET-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
208.3
MW (Da)
0.84
ALogP
4
HBA
0
HBD
34.1
PSA (Ų)
0.63
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor CHEMBL1907609 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL309 | IC50 | 6.63 | 5.85 | 233.0 | 2 |
| Muscarinic acetylcholine receptor M1 CHEMBL276 | IC50 | 6.38 | 6.38 | 412.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor | IC50 | = | 4.0 | nM | 8.4 | Compound was assessed for the binding affinity against muscarinic receptor subty... | - |
| Muscarinic acetylcholine receptor M2 | IC50 | = | 233.0 | nM | 6.63 | Muscarinic receptor M2 in rat heart using [3H]QNB (quinuclidinyl benzylate) radi... | - |
| Muscarinic acetylcholine receptor M1 | IC50 | = | 412.0 | nM | 6.38 | Binding affinity against Muscarinic receptor M1 in rat brain using [3H]-PZ (pire... | - |
| Muscarinic acetylcholine receptor M2 | IC50 | = | 8600.0 | nM | 5.07 | Binding affinity against Muscarinic receptor M2 in rat brain using [3H]QNB (quin... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00150-9 | Muscarinic acetylcholine receptor M2 | 2 |
| - | 10.1016/S0960-894X(97)00150-9 | Unchecked | 2 |
| - | 10.1016/S0960-894X(97)00150-9 | Muscarinic acetylcholine receptor M1 | 1 |
| - | 10.1016/S0960-894X(97)00150-9 | Muscarinic acetylcholine receptor | 1 |
Data from ChEMBL 36 via Core Engine