Assay Detail
Binding
CHEMBL748170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was assessed for the binding affinity against muscarinic receptor subtypes in rat brain using [3H]OXO-M radioligand as a muscarinic receptor agonist at a concentration of 0.2 nM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.53 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274329 | — | — | 1 | 9.10 |
| CHEMBL275104 | — | — | 1 | 8.80 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 8.70 |
| CHEMBL8610 | — | — | 1 | 8.40 |
| CHEMBL8510 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274329 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL275104 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL8610 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL8510 | — | IC50 | = | 23.0 | nM | 7.64 |